Our laboratory develops and applies mass spectrometric technology to study human health. We use these tools to answer fundamental questions in cell biology and to study human diseases including Alzheimer’s, diabetes, heart failure, cancer, obesity, asthma, among several others. The research team currently consists of twelve Ph.D. students, two postdoctoral fellows, two undergraduate researchers, and six staff scientists.
Our mission is to facilitate expedient, comprehensive analysis of biological molecules to advance biomedical research.
Untangling the multi-faceted networks that regulate complex organisms and their diseases will require innovative technologies to globally monitor many classes of biomolecules, including lipids, proteins, and metabolites. We aim to fill this technology gap by developing innovative mass spectrometry-based technologies.
The Coon Group’s most valuable resource is its collection of driven, energetic, and passionate researchers.
Scientists in the Coon Laboratory have diverse backgrounds and skill-sets making our group a veritable melting pot of ideas. Students and staff work together in small teams tackling exciting projects ranging from building new mass spectrometry instrumentation to analyzing the proteomes of human tissue specimens.
Occupying newly renovated space within the Genome Center of Wisconsin, we are nestled between Chemistry, Biochemistry, Genetics, Biomolecular Chemistry, and the Wisconsin Institutes for Discovery.
Our state-of-the-art laboratory houses approximately one dozen mass spectrometers, each equipped with gas or liquid chromatographs. We have a variety of hybrid mass spectrometer instrument configurations including quadrupole, quadrupole linear ion trap, and Orbitrap mass analyzers. This array of heavy mass spec artillery is complemented by more conventional laboratory instrumentation including plate readers, automated liquid handling robots, balances, centrifuges, etc.
Our laboratory is equipped with a dozen state-of-the-art hybrid mass spectrometers. With these systems, and close connections to our industrial partners, we innovate tomorrow’s mass spectrometry technology.
We are fortunate to house and operate the latest in high resolution, high performance mass spectrometer technology – including several of the latest generation Orbitrap systems. We have a long running collaboration with Thermo Fisher Scientific, the world’s leading MS manufacturer, and through these interactions have complete access to modify and develop on these fully functional MS platforms. We work closely with the UW’s patent foundation (WARF) to transfer our new technologies to industrial partners for commercialization. Since 2006, WARF has filed dozens of patent applications based upon our inventions, leading to several commercial products. Many of the technologies currently under development have the similar promise to impact hundreds of laboratories worldwide to solve countless biomedical questions.
In addition to our research in the lab, our group presents our research results all over the world and, occasionally, we kick back and relax together.
Typically each member of our team attends at least one national conference per year; however, we often present our work at international meetings in far away destinations including Stockholm, Paris, Kyoto, Taipei, Hong Kong, Tuscany, Vienna, and many others. When we are not in the lab or at a conference, we sometimes hang out together at Badger football games, in corn mazes, on Lake Mendota, or on the dodgeball court.
Latest From Coon Research Group
Brademan leads Argonaut software launch
Coon lab researchers, led by Dain Brademan, have launched a new software tool called Argonaut….Read More
New publication explores methods for rapid characterization of Monoclonal antibodies
Monoclonal antibodies (mAbs) are important therapeutic glycoproteins, but their large size and structural complexity make…Read More
Peters-Clarke explores efficient and effective peptide fragmentation in tandem MS
Photoactivation and photodissociation are useful tools in tandem mass spectrometry, but implementation often involves cumbersome…Read More
Nicholas Riley Featured in Badger Chemistry News
Nicholas Riley was featured in Badger Chemistry News! Read the interview here: https://badgerchemistnews.chem.wisc.edu/2018/07/11/nicholas-m-riley/Read More
The Yeast 3 Thousand (Y3K) dataset comprises over 1000 proteomes, 1000 lipidomes, and 1000 metabolomes, profiled with an aim of better understanding mitochondrial biology.
Learn more about the Y3K Project by reading the article in the November 2016 issue of Nature Biotechnology or from our Y3K website on the link below.
Coon Group Alumni
Even beyond the impact of our science, the most important product of our research is a rapidly growing cohort of alumni who are now engaged in the biomedical enterprise in various academic and industrial settings.
Earn your Ph.D. with us
The Coon Group is always on the lookout for new members. Professor Coon accepts students from several UW-Madison doctoral programs including Chemistry, the Integrated Program in Biochemistry (IPiB), and Cellular & Molecular Pathology.