Peters-Clarke explores efficient and effective peptide fragmentation in tandem MS

By November 4, 2020 No Comments

Photoactivation and photodissociation are useful tools in tandem mass spectrometry, but implementation often involves cumbersome and potentially dangerous configurations. To remedy this problem, Trent Peters-Clarke coupled a fiber-optic cable to an infrared (IR) laser on a mass spectrometer. His work shows that such fiber-assisted activated ion-electron transfer dissociation (AI-ETD) and IR multiphoton dissociation (IRMPD) experiments can be carried out as effectively as traditional mirror-based implementations. The configuration allows for a more robust, straightforward, and safe instrumentation on commercial mass spectrometers therefore broadening the accessibility of these techniques.

This research is described in a recent Analytical Chemistry publication titled Optical Fiber-Enabled Photoactivation of Peptides and Proteins.

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