We are excited to report that a recent collaborative project between the Coon and Wells groups has captured the attention of Steve Michnick, the father of protein complementation assays. Our collaborative article was recently published in Cell Chemical Biology. In Michnick’s review, More than One Way to Skin a Catalyst, he asserts that our novel technique may provide a general way to probe the wiring of signal transduction networks. This research importantly helps to inform our understanding of regulatory network problems and can offer “deeper insight into how living cells compute their responses to their environment and determine their fate.”