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Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys

By March 30, 2018 No Comments

Caloric restriction extends lifespan and delays aging in diverse species. On pp. 677–688 of the current issue of Cell Metabolism, Rhoads et al. integrated large-scale data from the hepatic transcriptome, proteome, and metabolome of rhesus monkeys after 2 years on a 30% calorie-restricted diet to reveal multi-modal mechanisms driven by calorie restriction to rewire metabolism. The panels of the cover image represent the four distinct regulatory strategies recruited by caloric restriction: transcriptional, post-transcriptional, translational, and post-translational, each of which gives a different “view” of the unified and integrated molecular response to caloric restriction.